Mass transfer stuck in one domain

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We are trying to model mass transfer across the blood brain barrier. The blood carries aptamers (the drug) into the capillary, then diffuses across the porous BBB layers surrounding the capillary. Aptamer diffusion in the capillary is modeled using transport of diluted species, while aptamer diffusion in the surrounding BBB layers is modeled using transport of diluted species in porous media. Despite setting inflow, outflow and continuity for all boundaries, the concentration gradient is still only available in the first domain, not diffusing through the following layers. Would anyone take a look at the COMSOL file and help us troubleshoot ? Mesh temporarily cleared for file size control here. Thank you very much.



0 Replies Last Post Jun 4, 2024, 8:15 p.m. EDT
COMSOL Moderator

Hello Vanessa Ji

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