Technical Papers and Presentations

Background: Even though the direct nose-to-brain drug delivery has multiple advantages, its application is limited by the low delivery efficiency (<1%) to the olfactory region with standard nasal devices. Novel delivery techniques are needed that can deliver clinically relevant dosage to the olfactory region. Our previous study has demonstrated that it is highly challenging to control ferromagnetic particles in a magnetic field due to the attractive force between a particle and the magnets. There will be a negligible force when the particle is far from the magnet, exerting no effective control on the particle motion; however, once the particle starts to move toward the magnets, it will moves faster and faster as the attractive force is in reverse proportional to the distance.