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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Multiphysics Simulation of Isoelectric Point Separation of Proteins Using Non-Gel Microfluidic System

A. Contractor[1], N. Xue[2], J.B.Lee[2], A. Balasubramanian[1], and G. Hughes[1]
[1]Lynntech, Inc., College Station, Texas, USA
[2]Micro Nano Devices and Systems (MiNDS) Laboratory, Department of Electrical Engineering, University of Texas at Dallas, Texas, USA

A portable device that can identify protein and peptides real time in complex biological systems such as human bodily fluids reliably and accurately is in high demand to properly diagnose and treat medical conditions. Lynntech has developed an innovative Polydimethylsiloxane (PDMS) based ... Read More

A Modular Platform for Cell Characterization, Handling, and Sorting by Dielectrophoresis

S. Burgarella[1], B. Dell’Anna[2], V. Perna[1], G. Zarola[2], and S. Merlo[2]

[1]STMicroelectronics, Agrate Brianza, MI, Italy
[2]Dipartimento di Elettronica, Università degli Studi di Pavia, Pavia, Italy

Dielectrophoresis (DEP) is a method for cell manipulation without physical contact in lab-on-chip devices, since it exploits the dielectric properties of cells suspended in a microfluidic sample, under the action of locally generated high-gradient electric fields. The DEP platform that ... Read More

Simulation Bubble Nucleation and Bubble Growth of a Thermal-Bubble Microejector

Z. Hongwei[1] and A.M. Gué[1]
[1]Laboratoire d’Analyse et d’Architecture de Systèmes, Université de Toulouse, Toulouse, France

The present study investigates simulation model and droplet ejection performance of a thermal-bubble microejector. This model simulates the bubble nucleation and the bubble growth, to predict the droplet ejection process. Specificity, it is achieved by coupling an electric-thermal model ... Read More

Mathematical Modeling of Zig-Zag Traveling-Wave Electro-Osmotic Micropumps

J. Hrdlicka[1], P. Cervenka[1], M. Pribyl[1], and D. Snita[1]
[1]Department of Chemical Engineering, Institute of Chemical Technology Prague, Prague, Czech Republic

In this paper we present results of the mathematical modeling of AC electroosmotic micropumps. Unlike others we use the full dynamic description, instead of the linearized model. Skewed hybrid discretization meshes are employed in order to accurately capture the main features of the ... Read More

Motion of Uncharged Particles in Electroosmotic Flow through a Wavy Cylindrical Channel

N. Qudus[1], T. Mahbub[1], S. A. Ali[1], and M. Shajahan[1]
[1] Bangladesh University of Engineering and Technology, Dhaka Bangladesh

A finite element model is employed to describe the electric potential distribution and electroosmotic flow field inside a wavy cylindrical channel. The model uses coupled Laplace and Poisson-Boltzmann to evaluate the electric potential distribution inside the channel. It also contains ... Read More

Numerical Investigation of Electroosmotic Flow in Convergent Divergent Micronozzle

V. Gnanaraj[1], V. Mohan[1], and B. Vellaikannan[1]
[1]Thiagarajar College of Engineering, Madurai, Tamilnadu, India

A fundamental understanding of the transport phenomena in microfluidic channels is critical for systematic design and precise control of such miniaturized devices towards the integration and automation of Lab-on- a-chip devices. Electroosmotic flow is widely used to transport and mix ... Read More

Microfluidic Separation System for Magnetic Beads

F. Wittbrach, A. Weddemann, A. Auge, and A. Hütten
Department of Physics, Bielefeld University, Germany

It is possible to control the motion of magnetic beads using a combination of hydrodynamic and electromagnetic forces. In this work, we investigate the possibility to manipulate the motion of beads with different magnetic moments in a special microfluidic structure so as to separate ... Read More

Mixing and Residence Time Distribution Studies in Microchannels with Floor Herringbone Structures

A. Cantu-Perez, S. Ping Kee, and A. Gavriilidis
University College London, Department of Chemical Engineering, Torrington Place, London, UK

The mixing characteristics and residence time distributions (RTDs) of a staggered herringbone microchannel have been investigated numerically by COMSOL Multiphysics and by particle tracking algorithms that incorporate diffusion via a random walk. All simulations were validated with ... Read More

Mixing of Liquids in Microfluidic Devices

B. Finlayson, A. Aditya, V. Brasher, L. Dahl, H. Dinh, A. Field, J. Flynn, C. Jenssen, D. Kress, F. Ninh, A. Nordmeier, H. Song, and C. Yuen

University of Washington, Seattle, WA, USA

The mixing of liquids was characterized in thirteen different microfluidic devices. The goal was to characterize, in a uniform manner, the flow and mixing that occurred in slow, laminar flow and to present the results that allow quick designs. The mixing of a dilute chemical in another ... Read More

CFD-based Evaluation of Drag Force on a Sphere Unsteadily Moving Perpendicularly toward a Solid Surface: a Simple Model of a Biological Spring, Vorticella Convallaria

S. Ryu[1], and P. Matsudaira[2]
[1]Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
[2]Department of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA

Vorticella convallaria, a sessile peritrich ciliate having a contractile stalk, is regarded as a model biological spring because of its remarkably fast contraction. Because the cell body shrinks to sphere-like shape during contractions, it can be assumed to be a sphere moving in ... Read More

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