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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Toward Nano-Scale Scanning Electrochemical Microscopy of Single Live Cells by Means of the COMSOL Multiphysics® software

Z. Ding [1], F. P. Filice [1], M. S. M. Li [1],
[1] Department of Chemistry, University of Western Ontario, London, ON, Canada

Scanning Electrochemical Microscopy (SECM) is a powerful noninvasive analytical technique employed in a variety of applications ranging from electrochemical characterization of material surfaces, to bioanalytical characterization of single live cells [1]. When applied to live cells, SECM ... Read More

Simulation of Magnetically Driven Peristaltic Pumps for Microfluidic Applications

L. Gritter [1], J. Crompton [1], K. Koppenhoefer [1], P. Nath [2]
[1] AltaSim Technologies, Columbus, OH, USA
[2] Applied Modern Physics, Los Alamos National Lab, Los Alamos, NM, USA

Microfluidic technologies can enable laboratory processes to be packaged in miniaturized and automated systems, allowing these processes to be performed with hand-held devices outside a laboratory environment. The practical usefulness of these “lab on a chip” systems has often been ... Read More

Nonhomogeneous Heat Transfer Simulation Using a Female Human Model

M. Castellani [1], T. Rioux [1], X. Xu [1],
[1] U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA

Previously researchers have modeled the human body using CAD software to create geometries that are approximately the same shape as the human body. While these CAD designs appear similar, they do not account for complex organ anatomy or sudden changes at the skin surface. Now, the human ... Read More

Dissolution Modeling of Uniform Aqueous Droplets in Two-Phase Flow in a Microfluidic Device

S. Onel [1, 2, 3, 4], U. Okumus [1], M. Toner [2, 3, 4],
[1] Department of Chemical Engineering, Hacettepe University, Ankara, Turkey
[2] Department of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA, USA
[3] Harvard Medical School, Boston, MA, USA
[4] Shriners Hospitals for Children - Boston, Boston, MA, USA

Safe preservation of mammalian cells for long term is essential for medical and pharmaceutical industries. Cryopreservation by conventional slow freezing and by vitrification below freezing temperatures are the most effective biopreservation methods compared to in vitro culture at ... Read More

Design of an Electro-Osmotic Microfluidic Mixer

T. Eppes [1], I. Milanovic [1], S. Keilich [1],
[1] University of Hartford, West Hartford, CT, USA

This paper explores the performance of a microfluidic mixer that uses a sinusoidal electric field to accelerate the diffusion process between two Newtonian liquid species in an electrolytic solution. The 2D model was developed using the Microfluidics module in the COMSOL Multiphysics® ... Read More

A Microfluidic Platform for Electrochemical Concentration and Detection

C. F. Ivory [1], D. E. Molina [1],
[1] Washington State University, Pullman, WA, USA

A poly(methyl methacrylate) (PMMA) microfluidic platform with a hot-embossed microchannel, 150 mm wide and 20 mm deep, was developed for multiple purpose detection using electrochemical methods. This device is able to accommodate a three-electrode system encased in 1/16" diameter PEEK ... Read More

Analysis of Mixing Chambers for the Processing of Two-Component Adhesives for Transport Applications

P. Steinert [1], R. Paul [1], I. Schaarschmidt [1], M. Zinecker [1], M. Hackert-Oschätzchen [1], Th. Muschalek [2], J. Esslinger [2], A. Schubert [1]
[1] Professorship Micromanufacturing Technology, Chemnitz University of Technology, Chemnitz, Germany
[2] Rublic+Canzler GmbH, Dresden, Germany

Two-component adhesives are commonly used for sealing and joining in transport applications for mechanically highly stressed connections. At the Chemnitz University of Technology an innovative system technology for the user-friendly, wireless and energy-efficient processing of two ... Read More

CFD Simulations to Improve Protein Separation Introducing a Permeable Surface with Periodic Grooves

M. Marioli [1], W. Th. Kok [1],
[1] Analytical Chemistry Group, van’t Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands

In this study, we use COMSOL Multiphysics® to improve protein separations by the analytical technique asymmetrical flow field-flow fractionation (AF4). AF4 is a very mild separation technique where separation of macromolecules or nanoparticles takes place along a ribbon-like channel that ... Read More

Interaction of Microparticles in a Miniaturized Vacuum-Cleaner

I. S. M. Jimidar [1], Y. Vanderheyden [1], H. Gardeniers [2], G. Desmet [1],
[1] Vrije Universiteit Brussel, Department of Chemical Engineering, Brussels, Belgium
[2] Universiteit Twente, Mesoscale Chemical Systems MESA+, Enschede, The Netherlands

The ever-growing complexity of samples which need to be processed in e.g., environmental and biomedical/biochemical research, demand higher efficiencies of analytical techniques. Liquid chromatography (LC), mass spectrometry, among others, are analytical techniques that revolutionized ... Read More

Simulation of CMOS Compatible Sensor Structures for Dielectrophoretic Biomolecule Immobilization

H. Matbaechi Ettehad [1], S. Guha [1], C. Wenger [1],
[1] IHP, Frankfurt (Oder), Brandenburg, Germany

The aim of this paper is to optimize with COMSOL Multiphysics® simulation, the design geometry of a near field biosensor which could be used for dielectrophoretic (DEP) immobilization and simultaneous sensing of biomolecules of the order of nanometers to micrometers. COMSOL Multiphysics® ... Read More

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